PRESENTATION

Loss of mobility in a part of the body, not being able to speak, remember or understand things, or smell or swallow food. A spinal cord or brain injury can change someone’s life both seriously and suddenly. Faced with this reality, there is a constant struggle to adapt to the new circumstances and overcome day-to-day obstacles. Together with patients, researchers make great efforts to minimise the damage caused by the injuries and to recover abilities that have deteriorated or been lost. We were told all about this by La Marató de TV3 and Catalunya Ràdio in 2010, when the telethon dealt with acquired spinal cord and brain injuries.


Awareness-raising, publicity and entertainment were combined during the 15 hours of live broadcasting, presented by the journalist Albert Om, and in the awareness-raising and publicity campaign that preceded it. As every year, this formula aroused the massive and enthusiastic participation of all of society: more than 1,300 local activities took place, 2,400 volunteers dealt with the donations in the call centres, 150,000 youngsters received one of the 3,500 talks that took place, and 150,000 copies of the La Marató disc and 10,000 of the book were sold. The voluntary involvement of hundreds of thousands of people, groups, institutions and companies left the scoreboard with final total of €8,735,103, which will be spent on biomedical research and raising public awareness of these diseases.

Now, in the Symposium that we are organising to close the cycle that began with La Marató 2010, we will learn about the skill and the painstaking work of the 55 research teams in the 30 projects that were funded from the donations that were collected, money that was translated into significant advances in the knowledge of acquired spinal cord and brain injuries. From sensory stimulation therapies that help to recover the ability to swallow, smell or speak, to ideas for regenerative medicine of damaged tissue, the results presented by the Foundation are focused on improving the quality of life of the people who have such an injury.

The 30 projects presented are those that achieved the highest score of the 100 that were presented in response to Foundation’s call. The Catalan Agency for Health Technology Assessment and Research co-ordinated a demanding process of international evaluation in which 111 specialists examined the quality, methodology, health and social relevance, innovative value, and viability of every candidate project.

The Symposium is a perfect meeting place for the scientists who have worked during these years on research into acquired spinal cord and brain injuries and the members of the public whose hard work has made possible this great boost to research that will have an impact on health. A new meeting of science with voluntary activity on the 25th anniversary of La Marató, in the unique setting of the Institute of Catalan Studies.

Single-centre projects
17
Co-ordinated projects
13

Of the twenty projects funded by La Marató 2009 almost half were co-ordinated, linking research groups in Catalan centres with others around Spain and in other countries, thereby boosting networking and the projection of the results.

PROJECTS

Novel neuropsychological assessment of frontal lobe lesions based on the hypothesis of dynamic neuroplasticity and compensation

Dr. Francisco Barceló Galindo
Institut Universitari d'Investigació en Ciències de la Salut, Universitat de les Illes Balears

> Results (in Catalan)> Report

Alterations of genome-wide DNA methylation during neural differentiation of adipose-derived stem cells: implications in regenerative medicine

Dra. María Berdasco Menéndez
Institut d'Investigació Biomèdica de Bellvitge
Dra. Consolación Melguizo Alonso
Centro de Investigación Biomédica de Granada

> Results (in Catalan)> Report

Early neurocognitive rehabilitation in critically ill patients with acute acquired brain injury

Dr. Lluís Blanch Torra
Hospital de Sabadell

> Results (in Catalan)> Report

Multicentric, controlled, randomized clinical trial to assess the efficacy and cost-effectiveness of urinary catheters with silver alloy coating versus conventional catheters in spinal cord injured patients

Dr. Xavier Bonfill Cosp
Centro Cochrane Iberoamericano. Hospital de la Santa Creu i Sant Pau

> Results (in Catalan)> Report

Nano-structured Electroactive Materials for Electrodes in Central Nervous System (CNS) stimulation and repair

Dra. Maria Nieves Casañ Pastor
Institut de Ciència de Materials de Barcelona
Dra. M. Cristina Suñol Esquirol
Institut d'Investigacions Biomèdiques de Barcelona
Dra. Ann Marie Rajnicek
Institut of Medical Sciences Aberdeen, UK

> Results (in Catalan)> Report

Sphingolipids as targets for the recovery from spinal cord injuries: Deciphering the role of sphingosine-1-phosphate

Dra. Josefina Casas Brugulat
Institut de Química Avançada de Catalunya CSIC
Dr. Rodrigo Martínez Maza
Hospital Nacional de Parapléjicos. Toledo
Dr. Antonio Delgado Cirilo
Facultat de Farmàcia UB

> Results (in Catalan)> Report

Boosting endogenous mechanisms for neural protection and repair after acute damage to the nervous system

Dra. Catalina Casas Louzao
Institut de Neurociències UAB
Dra. Valerie Petegnief
Institut d'Investigacions Biomèdiques de Barcelona
Dra. Assumpció Bosch Merino
Centre de Biotecnologia Animal i Teràpia Gènica UAB

> Results (in Catalan)> Report

Effect of afferent oropharyngeal pharmacological and electrical stimulation on swallow response and on activation of human cortex in stroke patients with oropharyngeal dysphagia (OD). A randomized controlled trial

Dr. Pere Clavé Civit
Hospital de Mataró

> Results (in Catalan)> Report

Proposal to improve Neurogenic Bowel Dysfunction and related Quality of Life outcomes in subjects with brain or spinal cord acute injury

Dra. Sílvia Delgado Aross
Institut de Recerca Hospital del Mar

> Results (in Catalan)> Report

Early implementation of music therapy in rehabilitation of aphasic patients after acute adquired brain injury / Efectivity of music therapy in the rehabilitation of acute aphasic patients

Dra. Carmen García Sánchez
Hospital de la Santa Creu i Sant Pau

> Results (in Catalan)> Report

Validation of mGlu4 as a therapeutic target for multipotential treatment of spinal cord injury

Dr. Jesús Giraldo Arjonilla
Institut de Neurociències UAB
Dr. Amadeu Llebaria Soldevila
Institut de Química Avançada de Catalunya CSIC
Dr. Cyril Goudet
Institut de Génomique Fonctionnelle, Montpellier

> Results (in Catalan)> Report

GODS project: genetic contribution to functional outcome and disability after stroke

Dr. Jordi Jiménez Conde
Institut de Recerca Hospital del Mar
Dr. Xavier Estivill Pallejà
Centre de Regulació Genòmica
Dr. Jerzy Krupinski
Hospital Universitari Mútua de Terrassa
Dr. Cristòfol Vives Bauzà
Hospital Universitari Son Espases Palma de Mallorca
Dr. Israel Fernández Cadenas
Institut de Recerca Hospital Universitari Vall d'Hebron

> Results (in Catalan)> Report

Optogenetic pacemaking to rewire neural circuits

Dr. Artur Llobet Berenguer
Facultat de Medicina CSUB
Dr. Pau Gorostiza Langa
Institut de Bioenginyeria de Catalunya IBEC

> Results (in Catalan)> Report

Effectiveness of psychoemotional support in Acute Spinal Cord Injury. ESPELMA project

Dra. Pilar Lusilla Palacios
Hospital Universitari Vall d'Hebron

> Results (in Catalan)> Report

Evaluation of acylethanolamide-based neuroprotectants in animal models of perinatal and adult brain hypoxia

Dr. Rafael Maldonado López
Laboratori Neurofarmacologia-Neurophar UPF
Dr. Fernando Rodriguez de Fonseca
Hospital Carlos Haya Málaga
Dr. Manuel Portavella García
Facultad de Medicina Universidad de Sevilla

> Results (in Catalan)> Report

Sonothrombolysis potentiated by microbubbles as a novel treatment of acute ischemic stroke: a prospective randomized study

Dr. Joan Martí Fàbregas
Hospital de la Santa Creu i Sant Pau

> Results (in Catalan)> Report

Impact of acute traumatic brain injury on the sense of smell: the role of smell training and neuroprotection in post-trauma smell recovery

Dr. Joaquim Mullol i Miret
Institut d'Investigació Biomèdica August Pi i Sunyer

> Results (in Catalan)> Report

Protection from stroke-induced neuronal injury by inhibition of autophagy. Role of Bmf and Noxa

Dra. Cristina Muñoz Pinedo
Institut d'Investigació Biomèdica de Bellvitge
Dr. Jochen Prehn
Neuroscience Research Centre, Ireland

> Results (in Catalan)> Report

Magnetoencephalography (MEG) and diffusion tensor magnetic resonance imaging (DTI) of functional and effective brain connectivity in traumatic brain injury

Dr. Rafal Nowak Zamojska
Fundación Centro Médico Teknon

> Results (in Catalan)> Report

Prospective study of bone loss after spinal cord injury. Risk factors and role of osteocyte markers

Dra. Pilar Peris Bernal
Hospital Clínic i Provincial de Barcelona

> Results (in Catalan)> Report

Neuropsychological rehabilitation after moderate and severe childhood TBI, a randomized study with parent-supported intervention, children with robotic intervention and control group

Dra. Pilar Póo Argüelles
Hospital Sant Joan de Déu
Dr. Xavier Vilasís Cardona
ETS Enginyeria, Electrònica i Informàtica La Salle

> Results (in Catalan)> Report

Neuroinflammation and adult neurogenesis after acute brain injury. Perspectives for neuronal recovery after brain damage

Dra. Esther Pozas Pulido
Institut d'Investigació Biomèdica August Pi i Sunyer

> Results (in Catalan)> Report

Quantitative analysis and computer aided simulation of minimally invasive approaches for intacranial vascular lesions

Dr. Alberto Prats Galino
Facultat de Medicina UB

> Results (in Catalan)> Report

PREDICTUS - Use of system biology to predict and diagnose transitory ischemia and ischemic tolerance

Dr. Francisco Purroy García
Hospital Universitari Arnau de Vilanova Lleida
Dr. Joaquim Egea Navarro
Facultat de Medicina UdL

> Results (in Catalan)> Report

Cognitive impairment induced by chemotherapy and radiotherapy. Evaluation of the impact and identification of clinical, neurophysiological and functional neuroimage risk markers

Dr. Antoni Rodríguez Fornells
Facultat de Psicologia CSUB

> Results (in Catalan)> Report

Modulation of immune receptors function as a novel therapeutic strategy for acute CNS damage

Dra. Carme Solà Subirana
Institut d'Investigacions Biomèdiques de Barcelona
Dra. Lydia Giménez Llort
Institut de Neurociències. UAB
Dr. Juan Sayós Ortega
CIBBIM - Nanomedicina Hospital Universitari Vall d'Hebron
Dr. Hugo Peluffo Zavala
Instituto Pasteur de Montevideo, Uruguay
Dr. Jordi Villà Freixa
Facultat de Ciències de la Salut i de la Vida UPF

> Results (in Catalan)> Report

Study and manipulation of Mfn2 gene expression in excitotoxicity

Dr. Francesc Xavier Soriano Zaragoza
Facultat de Biologia UB

> Results (in Catalan)> Report

Randomized controlled trial on the impact of cognitive telerehabilitation on cognition and quality of life in brain glioma patients

Dra. Pilar Teixidor Rodríguez
Hospital Universitari Germans Trias i Pujol

> Results (in Catalan)> Report

Non-invasive early neurophysiological interventions in brain and spinal cord injury patients

Dr. Josep Valls Solé
Hospital Clínic i Provincial de Barcelona
Dra. Hatice Kumru Cam
Institut Guttmann Hospital de Neurorehabilitació
Dr. Jordi Montero Homs
Hospital Universitari de Bellvitge

> Results (in Catalan)> Report

VIDEOS

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